Opportunity Information: Apply for RFA HL 18 020
The grant opportunity "Integrative Computational Biology for Analysis of NHLBI TOPMed Data" (Funding Opportunity Number RFA HL 18 020) is a discretionary NIH grant program from the U.S. Department of Health and Human Services, National Institutes of Health. Its central goal is to fund research teams that can carry out integrated, systems-level computational analyses using data produced by the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. In practical terms, the FOA is aimed at projects that combine whole genome sequencing with large-scale omics datasets (for example, transcriptomic, epigenomic, proteomic, metabolomic, or other high-throughput molecular profiles when available) alongside detailed phenotype and clinical information. The intent is not simply to analyze each data type in isolation, but to connect them through integrative computational biology approaches that can reveal how molecular networks and biological systems contribute to disease.
The scientific focus is squarely on conditions within the National Heart, Lung, and Blood Institute mission, specifically heart, lung, blood, and sleep-related diseases and traits. By supporting analyses that link genetic variation and multi-omic signals to clinical phenotypes, the FOA is designed to push beyond single-variant or single-assay discoveries and toward a more mechanistic understanding of disease biology. In other words, the program is positioned to help researchers map the molecular underpinnings of complex disease, identify pathways and networks involved in disease onset or progression, and potentially highlight targets or biomarkers that could inform precision medicine approaches over time.
From an applicant standpoint, eligibility is broad and includes many types of U.S. organizations: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other eligible tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions in those categories); for-profit organizations other than small businesses; small businesses; and other entities as allowed under the FOA’s additional eligibility language. This wide eligibility suggests NIH was seeking to attract multidisciplinary computational biology and data science capabilities wherever they reside, including academia, government, nonprofit research institutes, and industry.
Key administrative details include an award ceiling of $324,000 and an expected total of 12 awards. The FOA record lists a creation date of April 10, 2017, with an original closing date of July 6, 2018. The program is associated with multiple CFDA numbers (93.233, 93.837, 93.838, 93.839), reflecting alignment with several NIH/NHLBI funding areas. Overall, the opportunity is best understood as targeted support for teams that can leverage TOPMed’s rich whole genome and multi-omic resources, integrate them with deep phenotype and clinical data, and use systems approaches to generate biologically grounded insights into cardiopulmonary, hematologic, and sleep disease mechanisms.Apply for RFA HL 18 020
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Integrative Computational Biology for Analysis of NHLBI TOPMed Data" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839.
- This funding opportunity was created on Apr 10, 2017.
- Applicants must submit their applications by Jul 06, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $324,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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