Opportunity Information: Apply for CDC RFA GH 24 0097
This funding opportunity, titled "Strengthening Laboratory Capacity and Quality for HIV Diagnosis, Care, Treatment, and Monitoring in Malawi under PEPFAR" (Funding Opportunity Number CDC RFA GH 24 0097), is a CDC-led cooperative agreement focused on improving and sustaining Malawi's national laboratory system as the country works toward HIV epidemic control. The award is structured as technical and programmatic support delivered in close collaboration with the Malawi Ministry of Health, with an emphasis on building long-term national ownership rather than short-term service delivery. While the listed award ceiling for Year 1 is shown as 0 (meaning no fixed per-award cap is provided in the notice), CDC anticipates approximately $8,375,000 in total funding for the first fiscal year, contingent on available funds, and expects to make two awards.
The core purpose is to strengthen laboratory systems so that HIV diagnostics and monitoring are consistently available, accessible, and high quality across the country, while also addressing broader public health system gaps that affect testing performance. A central theme is sustainability: supporting the Ministry of Health to improve governance and stewardship of public health laboratory functions, reinforcing national structures so improvements continue after external support decreases. A related priority is strengthening National Reference Laboratories so they can better support surveillance and respond to outbreaks, recognizing that strong reference laboratory capacity benefits HIV programs and wider disease detection and response efforts.
On the service quality and patient outcomes side, the opportunity prioritizes improving viral load testing performance, particularly where viral load coverage and viral suppression are lagging among specific age groups and populations. The focus is not only on increasing the number of tests, but on using patient-centered approaches to understand why gaps occur (for example, access barriers, specimen referral issues, result return delays, or challenges with follow-up) and then implementing practical fixes across the diagnostic network. The opportunity also supports expanding and strengthening point-of-care testing platforms, with an explicit push toward integrated, multi-disease testing models rather than HIV-only approaches, which can improve efficiency and make testing more responsive to what patients and facilities actually need.
Another major component is quality management, especially for rapid testing. The grant highlights rapid testing continuous quality improvement (RTCQI) as a pathway to achieving national certification, signaling an intent to standardize and improve the reliability of rapid HIV testing across sites. Beyond rapid testing, the opportunity includes expanding external quality assessment (EQA) coverage so that multiple test parameters are routinely evaluated, helping detect performance problems early and ensuring labs maintain consistent accuracy over time. This quality focus also extends to preparing additional laboratories for ISO accreditation, which generally requires stronger quality systems, documentation, staff competency processes, equipment maintenance practices, and corrective and preventive action systems.
The notice also calls out several targeted diagnostic access gaps that affect clinical care and prevention. These include improving access to testing for advanced HIV disease (AHD), which is important for identifying and managing patients at higher risk of severe illness, and improving access to tests that support pre-exposure prophylaxis (PrEP) services, which are central to HIV prevention efforts. In parallel, the opportunity emphasizes regular diagnostic network optimization, meaning periodic, data-driven reviews of where instruments and testing sites are placed, how specimens move through referral routes, whether turnaround times are acceptable, and whether the network is operating efficiently and equitably. Related to this, it prioritizes increasing utilization of high-throughput instruments in conventional molecular laboratories to improve viral load coverage, which suggests a focus on making better use of existing capacity, reducing bottlenecks, and improving throughput where demand is high.
Finally, the opportunity explicitly includes strengthening biosafety and waste management, reflecting the operational realities of laboratory scale-up and the need to protect staff, patients, and communities. Better biosafety practices and proper waste handling are treated as essential system components, not optional add-ons, especially as testing expands and integrates across multiple disease areas. Overall, the grant is positioned as a comprehensive laboratory systems strengthening effort under PEPFAR, combining governance and sustainability goals with practical improvements in access, efficiency, quality assurance, and readiness for both routine HIV services and broader public health needs.
Key administrative details include: the opportunity is discretionary funding using a cooperative agreement mechanism (indicating substantial CDC involvement), falls under the health activity category, is associated with CFDA 93.067, lists eligible applicants as unrestricted, and had an original closing date of 2024-02-22, with the opportunity posted on 2023-11-21.Apply for CDC RFA GH 24 0097
- The Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Strengthening Laboratory Capacity and Quality for HIV Diagnosis, Care, Treatment, and Monitoring in Malawi under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on 2023-11-21.
- Applicants must submit their applications by 2024-02-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted.
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