Opportunity Information: Apply for RFA AI 22 070
The Autoimmunity Centers of Excellence (ACE), Basic Research Program (U19 Clinical Trial Not Allowed) is a National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) funding opportunity that supports participation in a multi-site cooperative research network focused on autoimmune disease. The overall ACE program is built around the idea that tight collaboration among basic and clinical investigators speeds up progress in understanding disease mechanisms and translating discoveries into better prevention and treatment strategies. While the ACE network includes both Basic and Clinical research programs, this particular announcement is specifically for the Basic Research program, with a separate companion announcement covering the Clinical program.
Under this FOA, funded teams are expected to carry out innovative basic research centered on human autoimmunity. Applications are structured around a combination of project types that can include Principal Projects, Pilot Projects, and Collaborative Projects. The emphasis is on mechanistic and pathogenesis-focused studies that deepen understanding of how autoimmune diseases start, evolve, and are sustained in people. Even though the Basic Research program does not itself support clinical trials (and this FOA explicitly states that clinical trials are not allowed), the basic science supported here is intended to connect directly with the broader ACE mission. In practical terms, that means Basic program awardees are expected to interact closely with investigators in the Clinical ACE program to help shape studies of autoimmune disease mechanisms and to inform the interpretation of immune-modulating interventions that are being evaluated in ACE clinical trials managed under the Clinical program. The cooperative agreement mechanism (U19) also signals that the NIH will have substantial scientific involvement during the award, reflecting the coordinated, networked nature of the ACE.
The funding instrument is a cooperative agreement (U19) within the health research activity category, listed under CFDA 93.855. The opportunity is identified as RFA-AI-22-070 and was created on 2022-12-22, with an original closing date of 2023-05-19. The listed award ceiling is $150,000 (as provided in the source data), and the opportunity anticipates making awards, though the provided record does not specify an exact number of expected awards.
Eligibility is broad and includes many types of domestic U.S. organizations and government entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; and Indian/Native American tribal governments other than federally recognized ones.
At the same time, the FOA draws clear boundaries around foreign participation. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply either. However, foreign components are allowed as defined in the NIH Grants Policy Statement, meaning a U.S.-based applicant may be able to include certain foreign elements in the project structure if they meet NIH policy definitions and requirements.
In short, this FOA funds coordinated, network-based basic research on human autoimmunity through the NIAID ACE program. It supports multi-project U19 applications that can integrate principal, pilot, and collaborative efforts, and it expects awardees to actively collaborate across the ACE network so that foundational mechanistic discoveries can directly inform (but not themselves conduct) clinical-trial-focused work happening in the companion Clinical ACE program.Apply for RFA AI 22 070
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Autoimmunity Centers of Excellence, Basic Research Program (U19 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2022-12-22.
- Applicants must submit their applications by 2023-05-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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