Opportunity Information: Apply for PAR 23 069
The HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (PAR-23-069) is an NIH grant opportunity designed to help certain NIH-funded pain management technologies move from the later stages of R&D into real-world commercialization. It focuses on small businesses that have already made substantial progress under prior NIH SBIR or STTR awards, specifically projects that were previously funded at the Phase II or Phase IIB level in pain management. The central idea is to provide targeted, practical support that makes a company more investable and more partner-ready, rather than funding additional basic research.
A key feature of this FOA is the emphasis on bringing experienced entrepreneurial talent directly into the small business team. The program supports the “embedded entrepreneur” model, where a person with commercialization and business development expertise is added to the leadership effort to strengthen go-to-market planning, sharpen the product story, validate market assumptions, and guide business strategy. Alongside this talent infusion, the award also supports commercialization-focused partnering activities aimed at securing private third-party funding or forming strategic partnerships with industry. In other words, the government funding is meant to de-risk and accelerate the steps that typically unlock follow-on private investment, licensing, co-development, distribution partnerships, or other industry-aligned commercialization pathways.
This is a discretionary grant program under the NIH, tied to the broader HEAL (Helping to End Addiction Long-term) initiative, and it sits in NIH’s health-related funding activity space. The opportunity is limited to eligible small businesses, and it is not open to non-U.S. (foreign) institutions. In addition, non-domestic components of U.S. organizations are not eligible to apply. However, the FOA notes that “foreign components,” as defined under the NIH Grants Policy Statement, may be allowed in some circumstances, which generally means a project might include certain foreign elements if they meet NIH policy definitions and are justified, but the applicant organization itself must remain eligible and U.S.-based under the FOA’s rules. Because those distinctions can be nuanced, applicants typically need to check the full FOA and NIH policy language to confirm whether any international subcontracting, collaboration, or other foreign involvement is permissible.
The funding instrument is a grant, and the award ceiling is listed as $400,000, indicating the maximum amount NIH expects to provide per award under this announcement. The listing does not specify the expected number of awards in the provided source data. The original closing date shown is 2025-09-05, which is the deadline applicants should work against unless NIH posts updates or changes. The opportunity is associated with multiple CFDA (Assistance Listing) numbers: 93.213, 93.350, 93.846, 93.853, and 93.867, reflecting the NIH programs and institutes/centers that may be involved in funding or administering awards under this solicitation.
Finally, the title includes “SB1 Clinical Trial Not Allowed,” which signals that the project activities proposed under this specific funding opportunity should not include clinical trials as defined by NIH. The intent is commercialization readiness and partnering support for pain management innovations that have already progressed through prior SBIR/STTR development stages, rather than initiating or conducting clinical trial work within this award. For applicants, that typically means framing the proposal around activities like partner outreach, investor materials, commercialization planning, product-market fit refinement, regulatory or reimbursement strategy planning (when allowed), and other business development steps that position the technology for private-sector financing or industry partnership.Apply for PAR 23 069
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.350, 93.846, 93.853, 93.867.
- This funding opportunity was created on 2023-01-03.
- Applicants must submit their applications by 2025-09-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: Small businesses.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 23 069) also looked into and applied for these:
| Funding Opportunity |
|---|
| Research Centers in Minority Institutions (RCMI) (U54 Clinical Trial Optional) Apply for RFA MD 23 001 Funding Number: RFA MD 23 001 Agency: National Institutes of Health Category: Health Funding Amount: $3,500,000 |
| Laboratories to Optimize Digital Health (R01 Clinical Trial Required) Apply for PAR 23 096 Funding Number: PAR 23 096 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tools and resources to understand the vascular pathophysiology of in vivo neuroimaging findings in TBI-related dementia and/or VCID (U24 - Clinical Trials Not Allowed) Apply for RFA NS 23 002 Funding Number: RFA NS 23 002 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Effectiveness of Implementing Sustainable Evidence-Based Mental Health Practices in Low-Resource Settings to Achieve Mental Health Equity for Traditionally Underserved Populations (R01 Clinical Trial Optional) Apply for PAR 23 092 Funding Number: PAR 23 092 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Initiation of a Mental Health Family Navigator Model to Promote Early Access, Engagement and Coordination of Needed Mental Health Services for Children and Adolescents (R01 Clinical Trial Required) Apply for PAR 23 094 Funding Number: PAR 23 094 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional) Apply for PAR 23 097 Funding Number: PAR 23 097 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical Trial Not Allowed) Apply for PAR 23 091 Funding Number: PAR 23 091 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional) Apply for PAR 23 093 Funding Number: PAR 23 093 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed) Apply for PAR 23 095 Funding Number: PAR 23 095 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Animal and Biological Material Resource Centers (P40) (Clinical Trials Not-Allowed) Apply for RFA OD 23 001 Funding Number: RFA OD 23 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required) Apply for PAR 23 070 Funding Number: PAR 23 070 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Independent Clinical Trial Not Allowed) Apply for PAR 23 071 Funding Number: PAR 23 071 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required) Apply for RFA NS 23 012 Funding Number: RFA NS 23 012 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Integrative Research to Understand the Impact of Sex Differences on the Molecular Determinants of AD Risk and Responsiveness to Treatment (U01 Clinical Trial Optional) Apply for PAR 23 082 Funding Number: PAR 23 082 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Programs for Inclusion and Diversity Among Individuals Engaged in Health-Related Research (PRIDE) (R25 Clinical Trial Not Allowed) Apply for RFA HL 24 004 Funding Number: RFA HL 24 004 Agency: National Institutes of Health Category: Health Funding Amount: $317,000 |
| Programs for Inclusion and Diversity Among Individuals Engaged in Health-Related Research (PRIDE) Coordination Center (U24 Clinical Trial Not Allowed) Apply for RFA HL 24 003 Funding Number: RFA HL 24 003 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| Mentored Career Development Program for Early Stage Investigators Using Nonhuman Primate Research Models (K01 Independent Clinical Trial Not Allowed) Apply for PAR 23 073 Funding Number: PAR 23 073 Agency: National Institutes of Health Category: Health Funding Amount: $75,000 |
| Pediatric Heart Network Clinical Research Centers (UM1 Clinical Trial Optional) Apply for RFA HL 24 001 Funding Number: RFA HL 24 001 Agency: National Institutes of Health Category: Health Funding Amount: $281,250 |
| Planning for the TMD Collaborative for IMproving PAtient-Centered Translational Research (TMD IMPACT) (R34 Clinical Trial Not Allowed) Apply for RFA DE 23 014 Funding Number: RFA DE 23 014 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Limited Competition: Pediatric Heart Network for the Data Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA HL 24 002 Funding Number: RFA HL 24 002 Agency: National Institutes of Health Category: Health Funding Amount: $2,105,263 |
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