Opportunity Information: Apply for PA 17 073
This NIH funding opportunity (PA-17-073) supports R01 research projects focused on understanding whether metformin, a widely used diabetes medication, has clinically meaningful effects on aging and age-related conditions beyond its established role as an antihyperglycemic drug. The program is rooted in observations from prior clinical studies across different patient groups suggesting metformin may influence biological pathways relevant to aging, prompting the need for more targeted translational research in humans. The overall goal is to generate evidence that clarifies metformin's potential to delay harmful age-related changes, preserve function, and possibly extend healthy human lifespan, while also sharpening the scientific rationale for larger future trials.
The FOA emphasizes two main types of projects. First, it encourages small-scale clinical and physiologic studies in humans designed to probe metformin's effects on aging-relevant outcomes, such as functional measures, metabolic and inflammatory markers, or other physiologic endpoints that can reveal how the drug influences systems that deteriorate with age. Second, it supports secondary analyses of existing controlled clinical intervention studies, including work using previously collected datasets and/or stored biospecimens. This second pathway is meant to maximize the value of completed or ongoing trials by allowing investigators to ask new aging-focused questions without necessarily launching a large, expensive new intervention study from scratch.
A central theme is identifying who is most likely to benefit. Applications are expected to help clarify which populations, subgroups, or phenotypes may respond particularly well to metformin in the context of aging biology. That could include differentiating effects by baseline metabolic status, comorbidities, frailty, age ranges, or other characteristics that influence risk and responsiveness. Another key objective is mechanistic insight in humans: investigators are encouraged to measure physiologic and cellular effects that can explain how metformin might act on aging-related pathways, and to use those findings to point toward novel molecular targets for future interventions. In practical terms, the FOA is looking for studies that do more than simply note an association; it aims to connect metformin exposure to interpretable human biological signals and clinically relevant aging outcomes.
The opportunity is offered as a discretionary grant under the NIH R01 mechanism, categorized under education and health-related federal assistance, with CFDA numbers 93.393 and 93.866. While the announcement does not specify an award ceiling or the expected number of awards in the provided source text, it is structured as a standard NIH research grant competition intended to fund hypothesis-driven projects that fit the FOA's translational aging goals.
Eligibility is broad and includes many types of organizations. Domestic applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations), indicating an intent to include a wide range of research-capable institutions and community-connected partners.
Key administrative details in the source include an original closing date of January 24, 2018, and a creation date of December 9, 2016. Overall, the FOA is best understood as an NIH effort to move metformin aging research toward actionable human evidence by funding smaller mechanistic clinical studies and rigorous re-analyses of controlled trial resources, with attention to identifying responder populations and clarifying biological mechanisms relevant to healthy aging.Apply for PA 17 073
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Potential Effects of Metformin on Aging and Age-Related Conditions: Small-Scale Clinical Studies and Secondary Analysis of Controlled Clinical Studies (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.866.
- This funding opportunity was created on 2016-12-09.
- Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Tobacco Use and HIV in Low and Middle Income Countries (R21) Apply for PAR 17 086 Funding Number: PAR 17 086 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| NLM Administrative Supplements for Informationist Services in NIH-funded Research Projects (Admin Supp) Apply for PA 17 090 Funding Number: PA 17 090 Agency: National Institutes of Health Category: Education, Health Funding Amount: $25,000 |
| Cancer Immune Monitoring and Analysis Centers (U24) Apply for RFA CA 17 005 Funding Number: RFA CA 17 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,400,000 |
| Cancer Immunologic Data Commons (CIDC) (U24) Apply for RFA CA 17 006 Funding Number: RFA CA 17 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: $900,000 |
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| Implementation Science for the Prevention and Treatment of Mental and/or Substance use Disorders in Low- and Middle-income Countries (U01) Apply for RFA MH 17 650 Funding Number: RFA MH 17 650 Agency: National Institutes of Health Category: Education, Health Funding Amount: $425,000 |
| HIV-1 infection of the Central Nervous System (R01) Apply for PA 17 100 Funding Number: PA 17 100 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Neuroscience Research on Drug Abuse (R01) Apply for PA 17 111 Funding Number: PA 17 111 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Neuroscience Research on Drug Abuse (R21) Apply for PA 17 112 Funding Number: PA 17 112 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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| Chronic Condition Self-Management in Children and Adolescents (R01) Apply for PA 17 115 Funding Number: PA 17 115 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Core "Center of Excellence" Grant Program (P30) Apply for PAR 17 121 Funding Number: PAR 17 121 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Reducing Health Disparities Among Minority and Underserved Children (R21) Apply for PA 17 117 Funding Number: PA 17 117 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Health Disparities Among Minority and Underserved Children (R01) Apply for PA 17 118 Funding Number: PA 17 118 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Chronic Condition Self-Management in Children and Adolescents (R21) Apply for PA 17 116 Funding Number: PA 17 116 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Overscreening for Breast, Cervical, and Colorectal Cancers among Older Adults (R01) Apply for PA 17 110 Funding Number: PA 17 110 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Discovering Novel Targets: The Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01) Apply for PA 17 120 Funding Number: PA 17 120 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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